Passive ventricular constraint

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Passive ventricular constraint prevents transmural shear strain progression in left ventricle remodeling.

BACKGROUND Passive ventricular constraint provides external cardiac support to reduce left ventricular (LV) wall stress and myocardial stretch, which are primary determinants of LV remodeling. Altered wall strain results in cytokine and reactive oxygen species production, which, in turn, stimulates apoptosis and extracellular matrix disruption and could be an important trigger for adverse globa...

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Shear properties of passive ventricular myocardium.

We examined the shear properties of passive ventricular myocardium in six pig hearts. Samples (3 x 3 x 3 mm) were cut from adjacent regions of the lateral left ventricular midwall, with sides aligned with the principal material axes. Four cycles of sinusoidal simple shear (maximum shear displacements of 0.1-0.5) were applied separately to each specimen in two orthogonal directions. Resulting fo...

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Evaluation of left and right ventricular diastolic function by electron-beam computed tomography in patients with passive epicardial constraint.

OBJECTIVE Previous investigations have shown the usefulness of electron-beam computed tomography (EBCT) to describe ventricular diastolic function and to detect constrictive filling pattern. We used EBCT to analyze diastolic function in patients who underwent passive epicardial constraint because data describing ventricular filling in these patients are still incomplete. METHODS Ten patients ...

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Passive ventricular constraint amends the course of heart failure: a study in an ovine model of dilated cardiomyopathy.

OBJECTIVE Dilated cardiomyopathy (DCM) is associated with a progressive deterioration in cardiac function. We hypothesised that some of the deleterious effects of DCM could be reduced by mechanically limiting the degree of cardiac dilatation. METHODS A Transonic 20A cardiac output (CO) flow-probe was implanted in the pulmonary artery of 12 adult (52 +/- 4 kg) sheep. Early heart failure was cr...

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The use of mechanical circulatory support and passive ventricular constraint in patients with acute and chronic heart failure

Many patients are diagnosed as having chronic heart failure (CHF) and apart from the fact that daily activities are impaired, they are great consumers of health care, and the prognosis is poor. The distinction between acute heart failure (AHF) and CHF may be difficult and is more a question of time rather than severity. The “gold standard” treatment for end‐stag...

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ژورنال

عنوان ژورنال: Progress in Biophysics and Molecular Biology

سال: 2003

ISSN: 0079-6107

DOI: 10.1016/s0079-6107(03)00016-6